py-ard

ARD reduction for HLA in Python

Human leukocyte antigen (HLA) genes encode cell surface proteins that are important for immune regulation. Exons encoding the Antigen Recognition Domain (ARD) are the most polymorphic region of HLA genes and are important for donor/recipient HLA matching. The history of allele typing methods has played a major role in determining resolution and ambiguity of reported HLA values. Although HLA nomenclature has not always conformed to the same standard, it is now defined by The WHO Nomenclature Committee for Factors of the HLA System. py-ard is aware of the variation in historical resolutions and grouping and is able to translate from one representation to another based on alleles published quarterly by IPD/IMGT-HLA.

Open Source

Freely available to use with source

Install from

The Python Package Index (PyPI)

Homebrew on Mac OS

Source

Reduction Types

Use py-ard to reduce and convert HLA typings to and from various representations.

Reduction Type	Description
`G`	Reduce to G Group Level
`P`	Reduce to P Group Level
`lg`	Reduce to 2 field ARD level (append `g`)
`lgx`	Reduce to 2 field ARD level
`W`	Reduce/Expand to 3 field WHO nomenclature level
`exon`	Reduce/Expand to exon level
`U2`	Reduce to 2 field unambiguous level
`S`	Reduce to Serological level

Using py-ard

py-ard can reduce typings from NMDP multiple allele code (MAC) designations, XX codes, as well as serologic nomenclature. Typings represented in GL String format is also well-supported.