ARD reduction for HLA in Python
Human leukocyte antigen (HLA) genes encode cell surface proteins that are important
for immune regulation. Exons encoding the Antigen Recognition Domain (ARD) are the most
polymorphic region of HLA genes and are important for donor/recipient HLA matching. The history of allele typing methods has played a major
role in determining resolution and ambiguity of reported HLA values. Although HLA nomenclature has not always conformed to the same standard, it is now
defined by The WHO
Nomenclature Committee for Factors of the HLA System.
py-ard is aware of
the variation in historical resolutions and grouping and is able to translate from one
representation to another based on alleles published quarterly by IPD/IMGT-HLA.